Welcome to Fleming Island Center for Clinical Research

Clinical trials move medicine forward. Sponsors, such as pharmaceutical companies, governments and foundations fund medical research. Patients who participate in clinical research receive many advantages including treatment at no cost, access to expertise and resources such as expensive tests. Research volunteers shape the future and can have fun while helping others and themselves.


As a premier clinical research organization, we have conducted more than 1,000 clinical trials over 20 years and have worldwide recognition for providing patients access to cutting edge medical research. If you have a medical issue and want a research solution, or if you are a healthy volunteer, come visit our center and learn more. One of our experts will be happy to evaluate you.

Shape the Future

Clinical research is a process that gives back. Volunteers generate information that improves future health care outcomes for everyone.

Find relief with new treatments

Volunteers join research to seek relief from affliction and to better understand their conditions with support from our caring team.

Programs Offer Resources or Pay

Study participants receive medical tests, services, counseling and treatment at no charge. These measures may be unavailable to the general public!

We do research in many areas

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Our Staff

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Dr. Mitchell Rothstein

Dr. Mitchell Rothstein is a Clinical Research Investigator at our Fleming Island research site and he has been with us for 5 years now. In February 2017, we are happy to say that Dr. Rothstein also became our new Phase 1 Medical Director at our Jacksonville University research site. We consider him an all-star at ENCORE Research Group, not only did he perform the first endobronchial stent in Jacksonville, but he also lettered in gymnastics in college. Which is probably why he handles working at two locations with ease.

In his free time, he collects animation art, especially the work of Chuck Jones, the famous Looney Tunes animator. Dr. Rothstein is a major sports fan. He loves watching mixed martial arts and is an Olympics sports addict. He is also a fan of the Jacksonville Jaguars, the New York Mets and the Jacksonville Jumbo Shrimp, our minor-league baseball team in Jacksonville.

While Dr. Rothstein has some downtime, he enjoys eating, he calls himself a ‘happy carnivore’! Some of his favorite TV shows to watch are: Fargo, Billions, Jeopardy, and Snapped. All in all, we’re glad we have Dr. Rothstein as part of our ENCORE Research team and we’re excited to see what he accomplishes with us in the years to come. 

Candy O’Neill

If you haven’t met Candy O’Neill, you’ve probably at least spoken with her over the phone! Candy has been with the Encore Research Group since 2004. She does a fantastic job working at the Fleming Island office as a Recruitment Specialist. In the past, she also worked from the Jacksonville office as a Recruitment Specialist and as a Patient Coordinator.

Candy’s passion is crafting; anything from paper crafts to clay pots and even gardening. She loves to watch HGTV and often turns to it for inspiration. If you haven’t heard some of Candy’s stories, just stick around because she always has an interesting story to tell.

Cindy Buda

"I do my part by managing the Fleming Island Office of Encore Research." On a daily basis I work as a Research Nurse Manager of our Fleming Island site supporting the Physician Investigators and staff in conducting clinical trials being carried out in our office. I am an original "Cheese Head" born in Green Bay Wisconsin and transplanted to Central Florida at the age of 10. I moved to Jacksonville for college and made Jacksonville my home. My greatest accomplishment is my four children. I enjoy family, cycling, travel and fishing.

Lastest Blog Post:

Great News about Hot Flashes!

Hot flashes and night sweats, medically known as vasomotor symptoms (VMS), are the most commonly reported menopausal symptom. A hot flash is “characterized by a sudden increase of blood flow, often to the face, neck, and chest, that causes the sensation of extreme heat and profuse sweating.” 1 Hot flashes are currently being studied around the world to better understand them. The great news for women struggling to deal with them is that answers are being found! Studies have already helped to clarify possible causes, what may trigger them, how they may relate to other health problems, how they affect quality of life, and what can be done to decrease them.

In a clinical trial of more than 3,000 midlife women, 60-80% experienced hot flashes at some point during the transition to menopause. During menopause, hormone levels fluctuate in the body, which has been shown to be associated with hot flashes.  Interestingly, scientists have found that even though all women have hormone changes during their menopause years, not all women have hot flashes.  Therefore, other factors must be involved, and further studies are needed.

Research has found that symptomatic women have small changes in core body temperature.  This is believed to trigger the body’s mechanisms to cool the body, resulting in sweating and hot flashes.  However, the promise of understanding and relieving hot flashes lies in continued research.

Women with hot flashes may be able to participate in helping to find answers which can lead to better treatments.  To learn more about current clinical trial opportunities for Hot Flashes, and other conditions please contact our office.


1.       http://www.obgyn.net/menopause/managing-menopause-part-1-vasomotor-symptoms
2.       NIH.gov

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